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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Francisco Rodriguez RP | 3 | 2 | 2 | 3.54 | 40 | 0 | 40.2 | 29 | 16 | 16 | 0 | 30 | 40 | 1.45 | .200 | .276 | 1.0 |
| Kevin Jepsen CL | 5 | 4 | 15 | 4.41 | 33 | 0 | 32.2 | 40 | 16 | 16 | 2 | 19 | 32 | 1.81 | .303 | .380 | 0.9 |
| Chris Bootcheck RP | 2 | 1 | 0 | 4.44 | 25 | 0 | 46.2 | 51 | 23 | 23 | 4 | 26 | 34 | 1.65 | .285 | .326 | 0.3 |
| Justin Speier RP | 0 | 2 | 0 | 4.70 | 21 | 0 | 30.2 | 32 | 22 | 16 | 10 | 8 | 25 | 1.30 | .278 | .272 | -0.6 |
| Ervin Santana SP | 6 | 6 | 0 | 4.80 | 18 | 18 | 105.0 | 104 | 61 | 56 | 19 | 35 | 88 | 1.32 | .259 | .286 | 1.2 |
| John Lackey SP | 6 | 7 | 0 | 4.83 | 19 | 19 | 113.2 | 115 | 67 | 61 | 20 | 29 | 86 | 1.27 | .263 | .284 | 1.3 |
| Jon Garland SP | 3 | 8 | 0 | 4.99 | 18 | 18 | 106.1 | 110 | 60 | 59 | 17 | 30 | 36 | 1.32 | .266 | .257 | 0.7 |
| Jered Weaver SP | 4 | 5 | 0 | 5.14 | 18 | 18 | 98.0 | 92 | 61 | 56 | 14 | 35 | 85 | 1.30 | .247 | .283 | 1.9 |
| Scot Shields RP | 2 | 0 | 1 | 5.34 | 31 | 0 | 28.2 | 29 | 17 | 17 | 3 | 18 | 21 | 1.64 | .269 | .302 | 0.1 |
| Darren O'Day RP | 0 | 4 | 2 | 5.45 | 36 | 0 | 34.2 | 39 | 23 | 21 | 8 | 14 | 34 | 1.53 | .271 | .304 | -0.1 |
| Joe Saunders SP | 5 | 7 | 0 | 5.71 | 17 | 17 | 88.1 | 101 | 60 | 56 | 13 | 41 | 50 | 1.61 | .290 | .302 | 0.7 |
| Darren Oliver RP | 0 | 5 | 1 | 8.05 | 40 | 0 | 38.0 | 61 | 36 | 34 | 10 | 16 | 26 | 2.03 | .370 | .392 | -0.5 |
| Jason Bulger RP | 2 | 1 | 2 | 9.93 | 30 | 0 | 29.0 | 35 | 32 | 32 | 8 | 25 | 30 | 2.07 | .299 | .342 | -0.8 |
